INI CET 2021 May


Antibiotic which interferes with protein metabolism:
a - Gentamicin
b - Chloramphenicol
c - Erythromycin
d - Vancomycin


Antimicrobial drugs according to Mechanism of action:

1.           Inhibit cell wall synthesis: Penicillins, Cephalosporins, Cycloserine, Vancomycin, Bacitracin.

2.           Cause leakage from cell membranes: Polypeptides—

Polymyxins, Colistin, Bacitracin. Polyenes—Amphotericin B, Nystatin, Hamycin.

3.           Inhibit protein synthesis: Tetracyclines, Chloramphenicol, Erythromycin, Clindamycin, Linezolid.

4.           Cause misreading of m-RNA code and affect permeability: Aminoglycosides— Streptomycin, Gentamicin, etc.

5.           Inhibit DNA gyrase: Fluoroquinolones—Ciprofloxacin and others.

6.           Interfere with DNA function: Rifampin.

7.           Interfere with DNA synthesis: Acyclovir, Zidovudine.

8.           Interfere with intermediary metabolism: Sulfonamides, Sulfones, PAS, Trimethoprim, Pyrimethamine, Metronidazole.